複眼のアーキテクチャを変化させる

Andrew C Zelhof¹, Robert W Hardy, Ann Becker

¹Howard Hughes Medical Institute and Department of Neurobiology, University of California at San Diego, La Jolla, California 92093-0649, USA. charles@flyeye.ucsd.edu

Nature

|October 13, 2006

まとめ

スペースメーカータンパク質は,昆虫の眼の発達を指揮する. その欠如は,オープンなラブドーム系を閉じたシステムに変換し,複合眼の構造と進化における重要な役割を明らかにします.

科学分野:

進化生物学の進化生物学について
発達生物学発達生物学とは
分子生物学は分子生物学である.

背景:

昆虫の複眼は,オープン・クローズド・ラブドーム系を含む多様な構造を示している.
光受容体細胞の特殊な区画であるラブドメアは,光検出に不可欠です.

研究の目的:

昆虫の目における開いたと閉じたラブドームシステムの間の移行の根底にある遺伝的メカニズムを理解する.
スペースメーカーを含む特定の遺伝子の,ラブドーメアの組立と組織における役割を特徴付ける.

主な方法:

ラブドメア組立に関与するドロソフィラの遺伝子の分離と特徴付け.
フルーツフライ (ドロソフィラ) のモデルにおけるSpacemaker発現の遺伝子操作.

主要な成果:

Spacemakerは,分泌されるタンパク質で,プロミニンとチャオプチンと連携して,オープンなラブドームシステムを確立します.
スペースメーカーの機能の喪失は,オープンなラブドームシステムを閉じたものに変えます.
閉じたシステムにおけるエクトピック・スペースメーカーの表現は,オープン・システムのようなアーキテクチャを誘導する.

結論:

Spacemakerは,ラブドーメアの分割と複合眼のアーキテクチャの重要な決定要因です.
スペースメーカーの機能の違いは,昆虫の視覚系形態変異に大きく影響する.
マイクロビラー組成と目の構造の進化的変化を理解するための分子的枠組みを提供します.

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