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Updated: Jul 13, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

5'-トリフォスファートRNAは,RIG-Iのリガンドである

Veit Hornung1, Jana Ellegast, Sarah Kim

  • 1Division of Clinical Pharmacology, Department of Internal Medicine, University of Munich, 80336 Munich, Germany.

Science (New York, N.Y.)
|October 14, 2006
PubMed
まとめ

5'-トリフォスファート末端を持つウイルスのRNAは,レチノ酸誘導性タンパク質I (RIG-I) によって検出されます. この未封鎖の5'-トリフォスファートRNA (3pRNA) は,RIG-I.によってウイルスの感染を検出するための分子シグネチャーとして機能します.

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