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Updated: Jul 19, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

FOXO1のCDK2依存型リン酸化は,DNA損傷に対するアポプトティック反応として機能する

Haojie Huang1, Kevin M Regan, Zhenkun Lou

  • 1Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

Science (New York, N.Y.)
|October 14, 2006
PubMed
まとめ

サイクリン依存キナーゼ2 (CDK2) は,FOXO1転写因子活性を制御することによって,DNA損傷後の細胞生存を調節する. DNA損傷はCDK2を阻害し,FOXO1のリン酸化を防止し,細胞死を促進します.

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