ダイヌスとエクソメチレンサイクル化合物の [2 + 2 + 2]サイクル添加によるキラルスパイロサイクル構造の高度なエナンチオセレクティブ構造

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Updated: Jul 19, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Kyoji Tsuchikama1, Yusuke Kuwata, Takanori Shibata

  • 1Department of Chemistry, School of Science and Engineering, Waseda University, Shinjuku, Tokyo, 169-8555, Japan.

Journal of the American Chemical Society
|October 19, 2006
PubMed
まとめ

研究者らは,エナチオセレクティブ [2 + 2 + 2] サイクロアディションを用いたキラル型スピロサイクリック化合物の作成のための新しい方法を開発しました. このロジウム触媒反応は,四次炭素中心を持つ分子を効率的に生成し,キラル化合物ライブラリを拡張します.

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