ELAM-1は,皮膚に宿るT細胞のための粘着分子です

L J Picker¹, T K Kishimoto, C W Smith

¹Department of Pathology, Stanford University School of Medicine, California 94305.

Nature

|February 28, 1991

まとめ

内皮細胞白血球粘着分子-1 (ELAM-1) は,皮膚血管アドレシンとして作用する. それは,急性炎症とは異なり,慢性炎症の部位に皮膚に宿るT細胞を選択的に結合します.

科学分野:

免疫学免疫学とは
細胞生物学細胞生物学
皮膚科皮膚科について

背景:

内皮細胞白血球粘着分子-1 (ELAM-1) は,急性炎症中の中性粒子の粘着に関与する誘導性分子です.
ELAM-1がT細胞結合,特に慢性炎症疾患において果たす役割は完全には解明されていません.

研究の目的:

ELAM-1とT細胞の相互作用を調査する.
ELAM-1が皮膚へのリンパ球の選択的徴募に作用するかどうかを判断する.

主な方法:

COS細胞をELAM-1で感染させる.
T細胞サブセットと中性粒子のELAM-1-トランスフェクト細胞への結合を評価する.
炎症した皮膚組織におけるELAM-1発現の免疫組織学的分析.

主要な成果:

ELAM-1-トランスフェクト細胞は,皮膚リンパ球関連抗原 (CLA) を発現する皮膚関連記憶T細胞のユニークなサブセットと結合します.
これらのCLA+T細胞は,中性粒子のようにELAM-1を効果的に結合するが,他の周辺血液リンパ球は結合が悪い.
血管のELAM-1発現は,慢性炎症の皮膚部位で優先的に観察されます.

結論:

ELAM-1は皮膚の血管アドレシンとして機能し,皮膚の記憶Tリンパ球の粘着を媒介する.
このメカニズムは,皮膚部位の慢性炎症性疾患に特異的です.
ELAM-1は,皮膚へのT細胞の組織選択的募集において重要な役割を果たします.

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