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Updated: May 5, 2026

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慢性多関節炎は,マクロファージの分解から脱出する哺乳類のDNAによって引き起こされる

Kohki Kawane1, Mayumi Ohtani, Keiko Miwa

  • 1Department of Genetics, Osaka University, Osaka 565-0871, Japan.

Nature
|October 27, 2006
PubMed
まとめ

DNase IIが欠けているマウスは,DNAが分解されていないために慢性多関節炎を発症します. これは腫瘍死滅因子アルファ (TNF-alpha) の生成を誘発し,関節炎やリウマチ性関節炎のような症状を引き起こす.

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