グリコプロテインCD44の新しい変異は,ネズミのがん細胞に転移の可能性を与える
U Günthert1, M Hofmann, W Rudy
1Institut für Genetik, Universität Karlsruhe, Federal Republic of Germany.
Cell
|April 5, 1991
まとめ
研究者らは,がん転移に関連した新しいCD44変異体pMeta-1を特定した. 転移しない細胞におけるこの変異体の過剰発現は,完全な転移行動を誘発し,腫瘍の広がりにおける重要な役割を強調した.
科学分野:
- 分子生物学は分子生物学である.
- がん研究 がん研究
- 免疫学 免疫学とは
背景:
- CD44は,細胞表面のグリコプロテインで,細胞粘着に関与しています.
- 転移は,がん細胞の複数の分子変化を含む複雑なプロセスです.
研究 の 目的:
- 癌の転移に関連した分子マーカーを特定するために.
- 腫瘍の進行における新しいCD44変異の役割を調査する.
主な方法:
- ネズミの臓がん細胞系におけるモノクローナル抗体ベースのスクリーニング.
- 新種の遺伝子変異を特定するために,cDNAのクローニングとシーケンシング.
- 転移するおよび転移しない腫瘍細胞系および正常組織における発現分析.
- 細胞系における遺伝子の過剰発現を含む機能的研究.
主要な成果:
- 部分的なCD44ホモロジーを持つグリコプロテインをコードするcDNAクローンの分離.
- 細胞外ドメインを挿入した新しい変種pMeta-1の特定.
- pMeta-1発現は,転移する腫瘍細胞系 (BSp73と13762NF) に限られている.
- 転移しない細胞におけるpMeta-1の過剰発現は,完全な転移の可能性を与えました.
結論:
- pMeta-1は,がん転移に関連するCD44の新しい変異体を表しています.
- pMeta-1変種は,転移行動の確立において重要な役割を果たします.
- この発見は,転移性がんの潜在的診断および治療標的を提供します.
関連する概念動画
02:30Histone Variants at the Centromere
5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
02:58Cell Potential and Free Energy
46.6K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.6K
01:21Matrix Proteoglycans and Glycoproteins
5.1K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
5.1K
00:52Potential Energy
42.7K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
01:09Potential Energy
1.0K
A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
1.0K
03:02Standard Electrode Potentials
50.4K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.4K