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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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関連する実験動画

Updated: May 8, 2026

A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

心血管疾患におけるヘッジホッグモルフォゲン

Maarten F Bijlsma1, Maikel P Peppelenbosch, C Arnold Spek

  • 1Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Circulation
|November 1, 2006
PubMed
まとめ

ヘッジホッグ (Hh) タンパク質ファミリーは,発達に不可欠です. このレビューは,心臓血管発達におけるHhシグナル伝達を探求し,Hh輸送における低密度リポタンパク質 (LDL) の新たな役割を提案しています.

科学分野:

  • 発達生物学 発達生物学について
  • 分子生物学は分子生物学である.
  • 心血管研究 循環器科の研究

背景:

  • ヘッジホッグ (Hh) タンパク質ファミリーは,胚の発達において根本的な役割を果たします.
  • Hhシグナル伝達経路は,細胞の成長,分化,組織パターニングを調節する.
  • Hhシグナル伝達の失調は,心血管疾患を含む様々な疾患に関与しています.

研究 の 目的:

  • ヘッジホッグ (Hh) タンパク質ファミリーの基本的な生物学と発達機能の見直し.
  • 心血管の発達におけるHhシグナル伝達とそのイシュケミアの役割について詳しく説明します.
  • 低密度脂質タンパク質 (LDL) を含むHh輸送のための新しいメカニズムを提案する.

主な方法:

  • ヘッジホッグ (Hh) 信号に関する既存の研究の文献レビュー.
  • 遺伝子発見,命名,経路メカニズムの分析.
  • 心血管発育とイシュケミアモデルに関連するHhシグナル伝達における最近の発見の議論.

主要な成果:

  • ヘッジホッグ (Hh) タンパク質ファミリーは,多様な発達プロセスに不可欠です.
  • Hhシグナル伝達は,心血管の発達に不可欠であり,イシュケミア研究において有望である.

さらに関連する動画

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

関連する実験動画

Last Updated: May 8, 2026

A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

  • 哺乳類のHh輸送を媒介する低密度リポタンパク質 (LDL) の仮説が提示されています.

    • 結論:

    • ヘッジホッグ (Hh) タンパク質は,心臓血管の健康に重要な役割を果たす重要な発達調節因子です.
    • 低密度脂質タンパク質 (LDL) は,哺乳類におけるHhタンパク質の新型トランスポーターとして機能する可能性がある.
    • この潜在的なLDL-Hh相互作用は,心血管疾患を理解し,治療するための新しい道を開きます.