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Updated: Mar 31, 2026

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
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Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Published on: September 21, 2021

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PGC-1alphaは,ハンチントン病の新たな治療標的である

Jetta K McGill1, M Flint Beal

  • 1Department of Neurology, Cornell Medical Center, New York, NY 10021, USA.

Cell
|November 4, 2006
PubMed
まとめ

エネルギー代謝に不可欠なコアクティベーターPGC-1αは,ハンティントン病 (HD) で下調調節されています. この発見は,ミトコンドリア機能の障害を,HD患者およびモデルにおける神経変性と関連付けています.

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