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Updated: May 5, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 18, 2011

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BRCA1/BARD1ヘテロダイマーがラン依存性ミトーシス・スピンドル・アセンブリを調節する

Vladimir Joukov1, Aaron C Groen, Tatyana Prokhorova

  • 1Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

Cell
|November 4, 2006
PubMed
まとめ

BRCA1/BARD1複合体は,染色体の安定性と腫瘍抑制に不可欠な機能であるミトスのスパインドル極の構築に不可欠です. このE3ユビキチン・リガゼの活動は,センターソームとは独立してスパインドルの組成を調節する.

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