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Updated: Jul 6, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

信号伝達ネットワークにおけるグローバル,インビヴォ,およびサイト固有のリン酸化ダイナミクス

Jesper V Olsen1, Blagoy Blagoev, Florian Gnad

  • 1Center for Experimental BioInformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense, Denmark.

Cell
|November 4, 2006
PubMed
まとめ

この研究では,タンパク質のリン酸化部位をマッピングするための質量スペクトロメトリー法が導入されています. これは,表皮成長因子 (EGF) の刺激がこれらの部位をダイナミックに変化させ,細胞シグナル伝達ネットワークの洞察を提供する方法を示しています.

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