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Updated: Jul 13, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

レセプターチロシンキナーゼとERKシグナリングのレギュレータのための機能的なRNAiスクリーン

Adam Friedman1, Norbert Perrimon

  • 1Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Nature
|November 7, 2006
PubMed
まとめ

この研究では,ドロソフィラの全ゲノムRNA干渉スクリーンを用いて,細胞外信号調節キナーゼ (ERK) 信号伝達の新しい調節体を特定しました. スクリーンは,Ste20のようなキナーゼとPPMファミリー・フォスファタゼを含む331の保存経路の調節体を明らかにし,潜在的な薬物標的を強調しました.

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