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Detection of Protein Ubiquitination Sites by Peptide Enrichment and Mass Spectrometry
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Detection of Protein Ubiquitination Sites by Peptide Enrichment and Mass Spectrometry

Published on: March 23, 2020

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トップダウンESI-ECD-FT-ICR質量スペクトロメトリーは,非共性タンパク質-リガンド結合部位を局所化する

Yongming Xie1, Jennifer Zhang, Sheng Yin

  • 1Department of Chemistry and Biochemistry and Department of Biological Chemistry, University of California--Los Angeles, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|November 9, 2006
PubMed
まとめ

電子捕捉解離 (ECD) 質量スペクトロメトリは,タンパク質のリガンド結合部位をマップすることができます. このテクニックは,非共性相互作用を保持し,アルファ-シヌクレインに結合する精子素を局所化し,タンパク質-リガンド相互作用の研究を進めています.

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関連する概念動画

Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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Conserved Binding Sites

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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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