アルフゾシン (Alfuzosin) は,良性前立腺肥大症の治療に使用されています. BPH-ALFグループについて
A Jardin1, H Bensadoun, M C Delauche-Cavallier
1Urology Service, Bicêtre Hospital, Paris, France.
Lancet (London, England)
|June 15, 1991
まとめ
アルフーゾシン (alpha1-adrenergic antagonist) は,プラセボと比較して,良性前立腺縮 (BPH) の症状を大幅に改善し,急性尿収留を減少させた. この研究は,BPH患者の長期的な有効性と安全性を確認しています.
科学分野:
- 泌尿器科 泌尿器科とは
- 薬理学 薬理学とは
背景:
- 良性前立腺増強症 (BPH) は,高齢の男性に多く見られる疾患です.
- 症状のあるBPHは,生活の質に大きな影響を与えます.
研究 の 目的:
- 症状のあるBPHの治療におけるアルフゾシンの長期的な有効性と安全性を評価する.
- アルフゾシンの効果とプラセボの効果を6ヶ月の期間で比較する.
主な方法:
- ランダム化制御試験で,症状のあるBPH患者518人が参加した.
- 患者は6ヶ月間アルフゾシン (7.5〜10mg/日) またはプラセボを投与されました.
- ボヤルスキー尺度,尿流量,残留体積測定を用いた症状評価.
主要な成果:
- アルフゾシングループにおける阻害性および刺激性BPH症状の有意な改善 (p = 0.0004).
- 効果の欠如とアルフゾシン群の急性尿収留の発生率の減少による中退率の低下.
- アルフゾシン治療で観察された平均尿流量増加と残量減少.
結論:
- アルフゾシンは,BPHの症状と尿流の改善に長期にわたる有効性を示しています.
- この薬はよく耐受され,プラセボと比較して同様の有害事象発生率があります.
- アルファ1 アドレナージックアンタゴニストは,症状のあるBPH患者にとって,有意かつ持続的な緩和をもたらす.
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