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関連する概念動画

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Updated: Jul 11, 2026

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells
08:03

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

Published on: October 20, 2015

癌の転移:枠組みを構築する

Gaorav P Gupta1, Joan Massagué

  • 1Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Cell
|November 18, 2006
PubMed
まとめ
この要約は機械生成です。

癌の転移は,遺伝的に不安定な細胞が新しい環境に適応し,腫瘍のストロマにサポートする特性を採用することを意味します. 技術の進歩により,この複雑な癌の拡散プロセスに関する理解が深まっています.

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
07:42

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

関連する実験動画

Last Updated: Jul 11, 2026

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells
08:03

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

Published on: October 20, 2015

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
07:42

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

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科学分野:

  • 腫瘍学 腫瘍学
  • 細胞生物学 細胞生物学
  • がん研究 がん研究

背景:

  • 転移は,癌の死亡率に決定的な複雑で多段階のプロセスです.
  • それは,がん細胞の適応と,遠くの組織マイクロ環境との相互作用を伴う.
  • 転移を理解することは,効果的ながん治療の開発の鍵です.

研究 の 目的:

  • 癌細胞が転移時に適応するメカニズムを解明する.
  • 転移性侵入を促進する腫瘍の微環境の役割を調査する.
  • 転移の理解における最近の進歩を強調する.

主な方法:

  • 癌転移に関する現在の文献のレビュー.
  • 転移性がん細胞における遺伝的不安定性の分析.
  • 侵襲性細胞との腫瘍ストロマの相互作用の調査.

主要な成果:

  • 転移は,癌細胞の遺伝的不安定性と適応を必要とする.
  • 腫瘍の微環境は,転移細胞を収容する上で積極的な役割を果たします.
  • 新しい概念的・技術的なツールにより,転移に関する研究が改善されています.

結論:

  • 癌の転移は,細胞適応とマイクロ環境の相互作用のダイナミックなプロセスです.
  • 新しいテクノロジーを活用したさらなる研究は,包括的な理解のために不可欠です.
  • 転移経路をターゲットにすることで,がん治療の有望性が見られます.