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関連する概念動画

Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Radical Chain-Growth Polymerization: Mechanism01:09

Radical Chain-Growth Polymerization: Mechanism

The radical chain-growth polymerization mechanism consists of three steps: initiation, propagation, and termination of polymerization. The polymerization initiates when a free radical generated from the radical initiator adds to the unsaturated bond in the monomer. The unpaired electron of the free radical and one π electron in the unsaturated bond creates a σ bond between the free radical and the monomer. As a result, the other π electron in the unsaturated bond converts this species into the...
Anionic Chain-Growth Polymerization: Mechanism01:04

Anionic Chain-Growth Polymerization: Mechanism

The mechanism for anionic chain-growth polymerization involves initiation, propagation, and termination steps. In the initiation step, a nucleophilic anion, such as butyl lithium, initiates the polymerization process by attacking the π bond of the vinylic monomer. As a result, a carbanion, stabilized by the electron‐withdrawing group, is generated. The resulting carbanion acts as a Michael donor in the propagation step and attacks the second vinylic monomer, which acts as a Michael acceptor.
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

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関連する実験動画

Updated: Jul 16, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
10:05

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

ポリモルフの選択を支える分子機構の洞察

Caroline Desgranges1, Jerome Delhommelle

  • 1Department of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29201, USA.

Journal of the American Chemical Society
|November 23, 2006
PubMed
まとめ

分子シミュレーションでは,安定性だけでなく結晶化運動が,コロイドサスペンションにおけるポリモルフの選択を決定することを明らかにしています. 複雑な成長メカニズムは,安定した構造に変換するメタステーブルな相を含む.

科学分野:

  • コロイド科学とは,コロイドの科学である.
  • マテリアルサイエンス 材料科学
  • クリスタル化・結晶化

背景:

  • ポリモルフの選択は結晶化プロセスにおいて極めて重要です.
  • 充電安定型コロイドサスペンションは,結晶化を研究するためのモデルシステムを提供します.
  • 熱力学と運動学の相互作用を理解することは不可欠です.

研究 の 目的:

  • 分子シミュレーションを使用して,コロイド結晶化中のポリモルフ選択を調査する.
  • ポリモルフの安定性に対する結晶化条件の影響を調査する.
  • 結晶の成長を制御する運動的メカニズムを解明する.

主な方法:

  • 負荷安定化コロイドサスペンションの結晶化をモデル化するために分子シミュレーションを使用しました.
  • ポリモルフの安定性を変化させるために結晶化条件を操作した.
  • 分子レベルで核形成と成長メカニズムを分析した.

主要な成果:

  • 結晶化条件を変更することによって,ポリモルフの安定性を逆転させる能力を示した.
  • 運動学が核形成と成長の両方に大きく影響することを観察した.
  • メタステーブルなポリモルフのクロス核化を伴う複雑な成長メカニズムを特定し,その後,安定した形態への変換を行った.

さらに関連する動画

Purification of the Dendritic Filopodia-rich Fraction
11:51

Purification of the Dendritic Filopodia-rich Fraction

Published on: May 2, 2019

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

関連する実験動画

Last Updated: Jul 16, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
10:05

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

Purification of the Dendritic Filopodia-rich Fraction
11:51

Purification of the Dendritic Filopodia-rich Fraction

Published on: May 2, 2019

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

結論:

  • 運動学は,熱力学的安定性が逆転した場合でも,ポリモルフの選択において支配的な役割を果たします.
  • 結晶の成長は必ずしも直接的なものではありませんが,中間的なメタステーブルな段階を含むことがあります.
  • 分子シミュレーションは,複雑な結晶化経路に関する重要な洞察を提供します.