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Updated: May 5, 2026

A Protocol for Using Förster Resonance Energy Transfer (FRET)-force Biosensors to Measure Mechanical Forces across the Nuclear LINC Complex
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Srcファミリーキナーゼ基質p130Casの機械的な拡張による力感知

Yasuhiro Sawada1, Masako Tamada, Benjamin J Dubin-Thaler

  • 1Department of Biological Sciences, Columbia University, Sherman Fairchild Center Room 715, MC-2416, 1212 Amsterdam Avenue, New York, NY 10027, USA. ys454-ind@umin.ac.jp

Cell
|November 30, 2006
PubMed
まとめ

細胞の力感知が明確にされる:p130Cas (Cas) タンパク質は,機械的ストレス下で拡張し,そのリン酸化を高め,下流の信号伝達経路を活性化します. これは,Casが物理的な力の重要なセンサーであることを明らかにしています.

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