アルコール摂取と心不全のリスクは,医師の健康調査Iで
Luc Djoussé1, J Michael Gaziano
1Division of Aging, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont St, 3rd Floor, Boston MA 02120, USA. ldjousse@rics.bwh.harvard.edu
Circulation
|November 30, 2006
まとめ
適度なアルコール摂取は,心不全 (HF) のリスクを軽減する可能性があります. 過剰な飲酒は避けるべきですが,適度な摂取は,潜在的に冠動脈疾患を改善することによって,心臓血管の利点を提供することがあります.
科学分野:
- 心臓病学 心臓病学
- エピデミオロジー エピデミオロジー
- 公衆衛生は公衆衛生である.
背景:
- 心不全 (HF) は,高齢者の入院の主な原因です.
- 40歳以上の成人の5人に1人は,HFを発症するリスクがあります.
- 適度なアルコール摂取とHFリスクに関する既存のデータは限られ,矛盾しています.
研究 の 目的:
- 適度なアルコール消費とインシデント心不全の発生リスクとの関連を調査する.
- アルコール摂取量の変動とHF発生率の関係を解明する.
主な方法:
- 医者の健康研究Iの21,601人の参加者を対象とした前向きなコホート研究.
- アルコール消費のベースライン評価と,1982年から2005年まで発生したHF症例のフォローアップ.
- HF症例は,アンケートを使用して特定され,Framingham基準を使用して検証され,共変数への調整が行われました.
主要な成果:
- 18.4年間の追跡期間中,904件のHF症例が記録されました.
- 適度なアルコールの摂取 (週5〜7杯) は,HFのリスクを低下させる傾向を示した (HR 0.84; 95% CI 0.71-0.99).
- より高い摂取量 (>7杯/週) は,HFのリスクが著しく低下する (HR 0.62; 95% CI 0.41-0.96) と関連していました.
結論:
- 適度なアルコール摂取は,心不全のリスクの低下と関連している可能性があります.
- HFに対する適度な飲酒の潜在的な利点は,冠動脈疾患に対する肯定的な効果と関連している可能性があります.
- 健康上のリスクがあるため,過度のアルコール摂取は避けるべきです.
関連する概念動画
01:27CNS Depressants: Alcohol and Nicotine
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
01:13Insufficient Sleep and Sleep Deprivation
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
01:24Substance Use Disorders Affecting Sleep
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
01:28Depressants
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
01:26Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
01:26Stress Prevention and Stress Management Techniques IV
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...