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Updated: May 7, 2026

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腫瘍遺伝子の誘発性衰老は,DNA超複製によって引き起こされるDNA損傷反応である

Raffaella Di Micco1, Marzia Fumagalli, Angelo Cicalese

  • 1IFOM Foundation-FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy.

Nature
|December 1, 2006
PubMed
まとめ

腫瘍遺伝子の活性化により,DNA複製ストレスが引き起こされ,DNA損傷反応 (DDR) が活性化されます. このDDRの強制は,腫瘍遺伝子の誘発性衰老 (OIS) に繋がり,細胞の変容と早期の腫瘍発生を防ぐ.

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