血清マクロ分子への直接的なアクセスは,赤血球内マラリア寄生虫によるものです
B Pouvelle1, R Spiegel, L Hsiao
1Department of Pathology and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107.
Nature
|September 5, 1991
まとめ
赤血球内のマラリア寄生虫は,伝統的な膜交差を回避して,栄養素の吸収のためにユニークな寄生虫管を利用します. この発見は,寄生虫の表面抗原に対する新しい治療標的を示唆しています.
科学分野:
- 細胞生物学 細胞生物学
- 寄生虫学とは,寄生虫学である.
- 免疫学 免疫学とは
背景:
- マラリア寄生虫プラズモディアム・ファルシパラムは,赤血球の中に宿主と寄生虫の膜によって隔てられている.
- これらの障壁を越えて栄養素の輸送を理解することは,抗マラリア戦略の開発に不可欠です.
研究 の 目的:
- マクロ分子が赤血球内のマラリア寄生虫にアクセスするメカニズムを解明する.
- マラリアに対する抗体媒介療法のための潜在的な標的を特定する.
主な方法:
- 寄生体の真空膜と赤血球膜の間の膜連続性の視覚化.
- 寄生虫の表面に,光マクロモレキュルのラベルを付け,エンドサイトーシスを遮断した状態で行います.
主要な成果:
- マクロモレキュルは,赤血球や寄生体の真空膜を通過しません.
- 寄生虫孔は,寄生虫を囲む水中の空間に直接アクセスします.
- 寄生虫は,この周囲のコンパートメントから,流体相内細胞分解を経由してマクロ分子を取り込みます.
結論:
- 寄生虫管は,腸内赤血球性マラリア寄生虫による栄養素の吸収のための重要な構造です.
- トロフォゾイトとスキゾントの表面抗原は,抗体指向の寄生虫駆除剤の有効な標的である.
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