関連する実験動画

Updated: Jul 18, 2026

Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
08:33

Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

Published on: September 21, 2021

[99mTc(CO) 3+と表示され,L型アミノ酸トランスポーターLAT1によって認識されるアミノ酸

Yu Liu1, Jae Kyoung Pak, Paul Schmutz

  • 1Institute of Inorganic Chemistry, University of Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland.

Journal of the American Chemical Society
|December 15, 2006
PubMed
まとめ

研究者らは,アミノ酸を使用して,L型アミノ酸トランスポーター (LAT1) を介して細胞に積極的に侵入する新しい金属複合体を開発しました. この画期的な発見により,金属にラベルを貼った分子が細胞内空間に標的を絞って送られるようになった.

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Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids07:26

Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids

Published on: January 26, 2012

Cell-Type Specific Protein Purification and Identification from Complex Tissues Using a Mutant Methionine tRNA Synthetase Mouse Line07:39

Cell-Type Specific Protein Purification and Identification from Complex Tissues Using a Mutant Methionine tRNA Synthetase Mouse Line

Published on: April 13, 2022

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Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

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Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Protein Transport into the Inner Mitochondrial Membrane01:34

Protein Transport into the Inner Mitochondrial Membrane

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tRNA Activation02:26

tRNA Activation

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Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...