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Updated: Jun 11, 2026

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
11:32

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

Published on: September 28, 2016

E-カデリンのトランスクリプトの5'-未翻訳領域に結合するように設計された細胞に浸透するペプチド核酸は,強力でシーケンス固有の反意味効果を誘発する

Anca Dragulescu-Andrasi1, Srinivas Rapireddy, Gaofei He

  • 1Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.

Journal of the American Chemical Society
|December 15, 2006
PubMed
まとめ

研究者らは,哺乳類の細胞における遺伝子発現を効果的に調節するグアニジンベースのペプチド核酸 (GPNA) を開発した. この細胞に浸透する分子は,タンパク質翻訳を阻害することによって,遺伝子を静止させるための毒性が低く,強力な方法を提供します.

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An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness06:21

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

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Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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