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Updated: Jul 9, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

タンパク質リガンドを設計するための構造に基づく二次構造独立アプローチ:Kv1.2カリウムチャネルブロッカーの設計への適用

C Magis1, D Gasparini, A Lecoq

  • 1Département d'Ingénierie et d'Etude des Protéines, DSV, CEA, CE-Saclay, 91191 Gif Sur Yvette Cedex, France.

Journal of the American Chemical Society
|December 15, 2006
PubMed
まとめ

私たちは,機能的モチーフを新しい宿主タンパク質に転送することによって,タンパク質リガンドを設計しました. この構造ベースの方法は,Kv1.2チャネル阻害剤を成功裏に生成し,タンパク質-タンパク質相互作用の調節のための新しいアプローチを示しました.

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