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Updated: May 6, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

7.9K

SCN9Aチャネル病変は,先天的に痛みを感じる能力が欠如することを引き起こします

James J Cox1, Frank Reimann, Adeline K Nicholas

  • 1Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.

Nature
|December 15, 2006
PubMed
まとめ

痛みを感じることが全くできない人は,珍しい遺伝疾患を持っています. この研究は,痛みのシグナル伝達に不可欠なSCN9A遺伝子の3つの新しい変異を特定し,この痛みの無感性を説明しています.

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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies08:16

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