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Updated: Jul 16, 2026

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ddIに対する耐性およびAZTに対する感受性は,HIV-1逆転写酵素の変異によって引き起こされる

M H St Clair1, J L Martin, G Tudor-Williams

  • 1Division of Virology, Burroughs Wellcome Co., Research Triangle Park, NC 27709.

Science (New York, N.Y.)
|September 27, 1991
PubMed
まとめ

HIV-1治療をジドボウジン (AZT) からディダノシン (ddI) に切り替えると,ddIの感受性が低下し,AZTの感受性が増加しました. 特定の突然変異が発生し,DDIに対する耐性を与え,AZTに対する耐性を抑制し,組み合わせ治療の重要性を強調した.

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