関連する実験動画

Updated: Jul 18, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

酵母内核酵素で生成されたDNAの断裂によって媒介される抗体クラスの切り替え

Ali A Zarrin1, Catherine Del Vecchio, Eva Tseng

  • 1Howard Hughes Medical Institute, Children's Hospital, CBR Institute for Biomedical Research, and Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 16, 2006
PubMed
まとめ

抗体クラススイッチング (CSR) は,スイッチ (S) 領域またはアクティベーション誘発型シチジンデアミナーゼ (AID) がなくても発生します. サイト固有のDNA二重鎖断裂 (DSB) はCSRを駆動することができ,CSRは一般的なDNA修復メカニズムから進化したことを示唆しています.

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Induction and Assessment of Class Switch Recombination in Purified Murine B Cells

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Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes08:12

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes

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