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Updated: Jul 18, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

PNA-DNAの二重,三重,四重はトランスサイクロペンタン単位で安定化されている

Ethan A Englund1, Qun Xu, Mark A Witschi

  • 1Laboratory of Bioorganic Chemistry, Department of Health and Human Services, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Journal of the American Chemical Society
|December 21, 2006
PubMed
まとめ

(S,S) -トランス・サイクロペンタン・ダイアミン単位を用いたペプチド核酸 (PNA) のバックボーン改変により,安定性が向上する. このtcypの組み込みは,生物医学的なアプリケーションのためのPNA-DNAの二重,三重,四重構造を改善します.

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