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Updated: Jul 18, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

GlcNAcstatin:ピコモラーで選択的なO-GlcNAcase阻害剤で,細胞内O-glcNAcylationレベルを調節する

Helge C Dorfmueller1, Vladimir S Borodkin, Marianne Schimpl

  • 1Division of Biological Chemistry & Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

Journal of the American Chemical Society
|December 21, 2006
PubMed
まとめ

研究者らは,O-GlcNAcase酵素の高度選択的阻害剤であるGlcNAcstatinを開発しました. この新しい化合物は,O-GlcNAcのレベルを効果的に上昇させ,細胞信号伝達経路の研究に強力なツールを提供します.

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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

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