血清25-ヒドロキシビタミンD濃度と多発性硬化症のリスク
Kassandra L Munger1, Lynn I Levin, Bruce W Hollis
1Department of Nutrition, Harvard School of Public Health, and Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA.
JAMA
|December 21, 2006
まとめ
高レベルのビタミンDは,多発性硬化症 (MS) のリスクの低下と関連しています. この前向きな研究では,25-ヒドロキシビタミンD濃度が高い個人が,特に白人集団では,MSを発症する可能性が著しく低いことが判明しました.
科学分野:
- 免疫学と神経学について
- 栄養学的流行病学について
背景:
- 重要な免疫調節剤であるビタミンDは,多発性硬化症 (MS) のリスクを軽減すると仮定されています.
- 現存する証拠は主に疫学的および実験的であり,前向きな研究が欠けている.
研究 の 目的:
- 血清の25-ヒドロキシビタミンD濃度とMSを発症するリスクとの関連を調べる.
- より高いビタミンD状態が,MS発生率の減少と相関するかどうかを判断する.
主な方法:
- 700万人以上の米軍関係者を対象とした,将来的な,内蔵されたケース・コントロール研究である.
- 257人の多発性硬化症患者の血清サンプルと対照群の25-ヒドロキシビタミンDレベルを分析した.
- ビタミンDの状態は,診断前の少なくとも2つの血清サンプルから平均で決定されました.
主要な成果:
- 白人の参加者の中で,25-ヒドロキシビタミンD濃度の上昇は,MSのリスクの低下と有意に関連していました (50 nmol/Lの増加でOR:0.59).
- ビタミンD濃度の最高クインチル (>99.1nmol/L) は,実質的なリスク低下 (OR:0.38) を示した.
- ベースラインのビタミンD濃度が低い黒人とヒスパニック人では,有意な関連は観察されなかった.
結論:
- 循環中の25-ヒドロキシビタミンD濃度の上昇は,多発性硬化症のリスクの低下と関連しています.
- この発見は,特に特定の人口集団において,MSの病原性におけるビタミンDの保護的役割を支持しています.
関連する概念動画
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:23Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
01:25Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:30Vitamins
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
01:22Connective Tissue Cell Types
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...