長期にわたるプロトンポンプ阻害剤療法と,股関節骨折のリスク
Yu-Xiao Yang1, James D Lewis, Solomon Epstein
1Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA. yangy@mail.med.upenn.edu
JAMA
|December 28, 2006
まとめ
陽子ポンプ阻害剤 (PPI) の長期使用は,特に高用量では,骨折のリスクが高いと関連しています. この研究は,長期のPPI治療に関連した潜在的な骨の健康上の懸念を強調しています.
科学分野:
- 胃腸内科と肝臓病理学について
- 骨代謝と骨粗鬆症について
- 医薬品監視 医薬品監視
背景:
- プロトンポンプ阻害剤 (PPI) は,カルシウム吸収と骨再吸収に影響を与える可能性があります.
- PPIが骨の健康に及ぼす二重の影響を理解することは極めて重要です.
研究 の 目的:
- プロトンポンプ阻害剤 (PPI) 治療と股関節骨折のリスクとの関連を調査する.
- PPIの使用期間と用量に関連して,股関節骨折のリスクを定量化するために.
主な方法:
- イギリスの一般医療研究データベース (1987年-2003年) を利用したネストケース・コントロール研究.
- 50歳以上の患者を含め,PPI使用者と非使用者を比較した.
- 性別,年齢,および追跡期間に関する対照群をマッチした; ヒスタミン2受容体アンタゴニストは比較のために使用された.
主要な成果:
- 13,000件以上の股関節骨折症例と130,000件以上の対照群を分析した.
- 1年以上のPPI治療では,股関節骨折の確率比が1.44増加しました.
- 長期にわたって高用量PPIを使用すると,股関節骨折のリスク (AOR2.65) が著しく上昇し,そのリスクは期間とともに比例して増加します.
結論:
- 長期にわたるプロトンポンプ阻害剤 (PPI) 治療は,股関節骨折のリスクの増加と関連しています.
- PPIの使用の高用量および長時間の使用は,より大きなリスクを伴います.
- 研究結果は,骨の健康に関連して,PPIの治療期間と投与量を慎重に検討することを示唆しています.
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