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Updated: Jul 17, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

発がん性ベンゾ[a]ピレン二酸化物エポキシドからの核酸添加物の高度にダイアステロ選択的合成と計算分析による解析

Mahesh K Lakshman1, John C Keeler, Felix N Ngassa

  • 1Department of Chemistry, The City College and The City University of New York, 138th Street at Convent Avenue, New York, New York 10031-9198, USA. lakshman@sci.ccny.cuny.edu

Journal of the American Chemical Society
|January 4, 2007
PubMed
まとめ

この研究は,デオキシアデノシン (dA) とデオキシグアノシン (dG) を含むベンゾ[a]ピレン (BaP DE-2) のシスダイオルエポキシド添加物のための新しいダイアステロセレクティブ合成を提示しています. この方法は,cis-dGアダクトの最初の合成と,dAアダクトとdGアダクトの両方の共通の中間物質を提供します.

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