ホモシステインの上昇は,左心室の機能の低下と関連している: 動脈硬化症の多民族研究
Khurram Nasir1, Michael Tsai, Boaz D Rosen
1Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Circulation
|January 4, 2007
まとめ
ホモシステイン (Hcy) 濃度の上昇は,無症状の個体における左心室内静脈機能の低下と関連している. この発見は,Hcyが症状が現れる前に心臓の健康に影響を与える可能性があることを示唆しています.
科学分野:
- 心臓病学 心臓病学
- バイオケミストリー バイオケミストリー
- メディカルイマージング (医学イメージング)
背景:
- ホモシステイン (Hcy) の上昇は,心不全の潜在的な危険因子です.
- 以前の研究では,特定の集団におけるHcyと心臓病との関連が示唆されています.
研究 の 目的:
- ホモシステイン濃度と地域左心室機能の関連性を調査する.
- 先進的なイメージング技術を使用して,無症状の集団における心臓機能を評価する.
主な方法:
- タグ付けされた磁気共鳴画像 (MRI) を利用し,多民族性動脈硬化症研究 (MESA) の1178人の参加者を対象とした.
- 計算された地域ピークシストリックミッドウォールの周回線株,冠動脈領域によって左心室領域を定義する.
- 伝統的な心血管疾患の危険因子,人口統計,動脈硬化症の測定値に調整されています.
主要な成果:
- 減少した地域性心筋回周縮は,プラズマのHcyレベルに関連して,左側前部下降領域と左側回転領域で観察されました.
- 周回性シストリック機能不全は,これらの地域における高値のログ変換 Hcy レベルと有意な関連性を示した.
- 縮小された左心室のストレンの確率の増加は,分析されたすべての冠動脈領域でより高いHcyレベルで見つかりました.
結論:
- 高濃度のホモシステインは,無症状のコホートにおける左心室のシストリック機能の低下と関連しています.
- タグ付けされたMRIは,Hcy.に関連した心臓機能の微妙な低下を検出することができます.
- これらの発見は,亜臨床性心機能障害の潜在的なバイオマーカーとしてHcyを強調しています.
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