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Updated: May 5, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

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ユビキチネーションはPTENの核輸入と腫瘍抑制を調節する

Lloyd C Trotman1, Xinjiang Wang, Andrea Alimonti

  • 1Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Cell
|January 16, 2007
PubMed
まとめ

核PTENは腫瘍抑制に不可欠であり,その輸入はモノウビキチン化によって媒介されます. 癌に関連したPTEN変異は,このプロセスを破壊し,タンパク質の安定性に影響を及ぼすことによって腫瘍の進行に影響を与えます.

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