コメント on "一般的な遺伝子変異が成人および子供の肥満と関連している"
Ruth J F Loos1, Inês Barroso, Stephen O'rahilly
1Medical Research Council Epidemiology Unit, Cambridge, UK. ruth.loos@mrc-epid.cam.ac.uk
まとめ
INSIG2遺伝子の近くのrs7566605遺伝子の変異は,以前により高いボディマス指数 (BMI) と関連していた. 私たちの研究では,この変種とBMIの間の関連性は,大規模なコホートでは見つかりませんでしたが,遺伝的発見の潜在的不一致を示唆しています.
科学分野:
- 遺伝学 遺伝学とは
- メタボリック・ヘルス メタボリック・ヘルス
- 人口研究 人口研究
背景:
- rs7566605単核酸多形態 (SNP) は,インスリン誘導遺伝子2 (INSIG2) 遺伝子の上流に位置しています.
- 以前の研究では,rs7566605とボディマス指数 (BMI) の増加との間の一貫した関連が示唆されていました.
研究 の 目的:
- rs7566605の遺伝子変異とボディマス指数 (BMI) の関連性を調査する.
- ハーバート等の研究結果を検証または反論する. rs7566605-BMIの独立コホートにおける関連について.
主な方法:
- 2つの大きな,民族的に均質な人口ベースのコホートからの遺伝子データの分析.
- rs7566605変異のゲノタイプ化について.
- 遺伝子変異と測定されたBMIとの関連を特定するための統計分析.
主要な成果:
- rs7566605変種とBMIとの間に統計的に有意な関連性を示す証拠は見つかりませんでした.
- 以前報告された関連性の反対の方向の傾向が観察されましたが,統計的に有意ではありません.
結論:
- rs7566605変種と,ハーバートらによって報告されたBMIとの関連性. これらの大規模で均質な集団では複製されていませんでした.
- rs7566605変種が体量調節における役割と潜在的な集団特異的な効果を明らかにするために,さらなる研究が必要である.
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