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Updated: Jul 13, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

Ubiquitinのようなタンパク質チオエステルスイッチの基礎として,E1-E2親和性を切り替えるE1-E2親和性を切り替える.

Danny T Huang1, Harold W Hunt, Min Zhuang

  • 1Howard Hughes Medical Institute, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Nature
|January 16, 2007
PubMed
まとめ

この研究は,ユビキチン状タンパク質 (UBL) 結合酵素が,チオエステルメカニズムを通じて結合親和性を切り替える方法を明らかにしています. この形状の変化は,UBLの改変経路の連続的なステップを駆動する.

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