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Updated: May 3, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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有害な化合物は,システインの共振変異によってTRPA1イオンチャネルを活性化します

Lindsey J Macpherson1, Adrienne E Dubin, Michael J Evans

  • 1Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Nature
|January 24, 2007
PubMed
まとめ

刺激物質によって活性化されるTRPA1チャネルは,結合的に変異するシステイン残留物によって痛みをシグナルする. この共性結合,特に反応性システインの結合は,チャネル活性化と疼痛信号を誘発する.

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