Jove
Visualize
お問い合わせ

関連する概念動画

Machines01:19

Machines

Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
Cable Subjected to a Distributed Load01:24

Cable Subjected to a Distributed Load

The analysis of suspension bridges is a complex and critical process that involves multiple factors, including the shape and tension of the main cables. The main cables of suspension bridges are subjected to distributed loads, which result in changes in tensile forces and deformation of the cable. These loads must be carefully considered to ensure that the bridge is safe and capable of supporting the weight of different loads.
Parallel Processing01:20

Parallel Processing

The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
Single Pipe Systems01:24

Single Pipe Systems

In pipe flow analysis, problems are typically categorized into three types — Type I, Type II, and Type III — based on the known parameters and the desired outcome. Each type of problem addresses specific engineering requirements using fluid properties, pipe characteristics, and operational conditions.
In a Type I problem, fluid properties (density and viscosity), pipe characteristics (including diameter, length, and surface roughness), and the flow rate or average velocity are known. The...
Multiple Pipe Systems01:21

Multiple Pipe Systems

Multipipe systems consist of complex configurations of interconnected pipes designed to transport fluids efficiently across intricate networks. They are essential in engineering applications requiring precise control over flow distribution, pressure, and head loss. They are categorized into series, parallel, loop, and network configurations, each distinguished by unique flow characteristics and applications.
Series Configuration
In a series configuration, fluid flows sequentially from one pipe...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Three New Calcium Formate Reference Materials for δ<sup>13</sup>C Measurements and a Redetermination of the R(<sup>13</sup>C/<sup>12</sup>C) Ratio for VPDB Based on Proton Nuclear Magnetic Resonance Measurements.

Rapid communications in mass spectrometry : RCM·2026
Same author

Rethinking the Terms "π-Stacking" and "π-π Stacking" Again: A Proposal to Clarify the Language of Aromatic Interactions.

Journal of the American Chemical Society·2026
Same author

Position-Specific Carbon Isotope Fingerprinting of Fluorinated Organics and Degradation Products.

Analytical chemistry·2026
Same author

An Investigation of Nirmatrelvir (Paxlovid) Resistance in SARS-CoV-2 M<sup>pro</sup>.

ACS bio & med chem Au·2024
Same author

High-Resolution Substrate Specificity Profiling of SARS-CoV-2 M<sup>pro</sup>; Comparison to SARS-CoV M<sup>pro</sup>.

ACS chemical biology·2024
Same author

Position-specific carbon stable isotope analysis of glyphosate: isotope fingerprinting of molecules within a mixture.

Analytical and bioanalytical chemistry·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する実験動画

Updated: Jul 6, 2026

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
08:28

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Published on: May 26, 2016

硬直したスレッドビスインターケレーターの構造特性

Yongjun Chu1, Steven Sorey, David W Hoffman

  • 1Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.

Journal of the American Chemical Society
|February 1, 2007
PubMed
まとめ

研究者は,NMRを用いた新しいバイインターケレーター (C1) とのDNA相互作用を研究した. 硬いリンクは,分子をDNAのマイナー・グリューブに誘導し,多様性のあるシーケンス固有の結合能力を示します.

科学分野:

  • 分子生物学は分子生物学である.
  • 生物物理化学 生物物理化学
  • 構造生物学 構造生物学とは

背景:

  • DNA結合分子は,遺伝的プロセスを理解し,治療法を開発するために不可欠です.
  • 糸状バイインターカレーターは,配列特異的なDNA認識のためのユニークなメカニズムを提供します.
  • 以前の研究では,柔軟なリンクヤーが考察されたが,硬いリンクヤーでは新しい設計の可能性がある.

研究 の 目的:

  • 厳格なスパイロリンクナーを備えた新しいスレッドビシンターケレーター (C1) の配列特異的なDNA結合を調査する.
  • 核磁共振 (NMR) スペクトロスコピーを用いてC1-DNA相互作用の構造的基礎を解明する.
  • C1の結合モードを,以前に研究された柔軟なリンクアノログと比較するために.

主な方法:

  • 距離制約を決定するための溶液核磁共鳴 (NMR) スペクトロスコーピー.
  • 構造的検証のためにPf1-phageを用いた残留二極結合 (RDC) 測定.
  • C1-DNA複合体の構造モデルを生成するための計算モデリング.

主要な成果:

  • 構造モデルにより,C1バイインターカレーターは,d(CGGTACCG) ((2) のDNA配列に結合することを明らかにした.

さらに関連する動画

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Bilayer Microfluidic Device for Combinatorial Plug Production
07:03

Bilayer Microfluidic Device for Combinatorial Plug Production

Published on: December 1, 2023

関連する実験動画

Last Updated: Jul 6, 2026

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
08:28

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Published on: May 26, 2016

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Bilayer Microfluidic Device for Combinatorial Plug Production
07:03

Bilayer Microfluidic Device for Combinatorial Plug Production

Published on: December 1, 2023

  • 硬いリンカーの中央のサイクロヘクサンのリングは,DNAのマイナー・グリューブの内側に平坦に位置しています.
  • シーケンス特異性は,リンカー長,水素結合,ステリック,水害性相互作用によって影響を受けます.
  • 結論:

    • 硬いスパイロリンクは,DNAマイナー・グリューブ内のバイインターカレーターのシーケンス固有の結合を促進します.
    • この結合モードは,メジャー・グリューブで結合する柔軟なリンクヤーと対照的であり,スレッドポリインターケレーションの汎用性を強調しています.
    • 発見は,調整可能な配列特異性を持つ新しいDNA相互作用剤の設計に関する洞察を提供します.