関連する実験動画

Updated: Jul 14, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

DEAD-box RNAヘリカーゼDbp5は,トランスレーション・ターミネーションで機能する

Thomas Gross1, Anja Siepmann, Dorotheé Sturm

  • 1Institut für Molekularbiologie und Tumorforschung der Philipps-Universität Marburg, Emil-Mannkopff-Strasse 2, 35037 Marburg, Germany.

Science (New York, N.Y.)
|February 3, 2007
PubMed
まとめ

DEAD-box RNAヘリカーゼDbp5は,真核細胞の翻訳終結に不可欠である. 放出因子 eRF1 および eRF3 と相互作用し,適切なストップコドン認識と効率的なタンパク質合成のための複合体の形成を保証します.

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Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...