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Updated: Jul 7, 2026

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Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
正常な血圧,前高血圧,高血圧が冠動脈マイクロ血管機能に及ぼす影響
Dogan Erdogan1, Ibrahim Yildirim, Ozgur Ciftci
1Baskent University, Konya Teaching and Medical Research Center, Cardiology Department, Hoca Cihan Mah, Saray Cad, No. 1, Selcuklu, Konya, Turkey. aydoganer@yahoo.com
Circulation
|February 7, 2007
まとめ
冠動脈フロー・リザーブ (CFR) は,高血圧前症候群の個体において低下し,心血管損傷の早期徴候を示す. この障害は,既定の高血圧よりも軽度である.
科学分野:
- 心臓病学 心臓病学
- 血管生理学 血管生理学
- 診断用イメージング
背景:
- トランストラシック・ドップラー心声検査で評価される冠動脈流量準備 (CFR) は,高血圧の末端器官損傷の認識された指標です.
- 以前の研究では,高血圧前の臨界期である高血圧前の臨界期である前高血圧を有する個体において,CFRを評価していなかった.
研究 の 目的:
- 前高血圧と診断された被験者の冠動脈流量準備量 (CFR) を調査し,定量化する.
- 前高血圧,既定高血圧,および健康な対照群のCFRレベルを比較する.
主な方法:
- トランストラシック・ドップラー心拍は,高血圧前の40人の被験者,高血圧の60人の被験者,および50人の健康な対照群でCFRを測定するために使用されました.
- 人口,臨床,生化学のパラメータは,CFRとの類似性と相関性を分析した.
主要な成果:
- CFRは,対照群と比較して高血圧前のグループで有意に低かった (2.54+/-0.48対2.91+/-0.53).
- 高血圧グループは,最も低いCFR (2.23+/-0.47) を示し,前高血圧と高血圧の両方がCFRの低下の有意な予測要因であった.
- CFRは,血圧,年齢,hs-CRP,心臓の構造的/機能的パラメータと逆相関を示し,同時にミトラルE/A比率と正相関を示した.
結論:
- 冠動脈フロー・リザーブ (CFR) は,高血圧前症患者において明らかに低下しています.
- この障害は,有意ではあるが,既定の高血圧の患者に見られるよりも顕著ではないため,高血圧前症は心血管障害の初期段階であることを示唆している.
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