大動脈動脈瘤は動脈硬化によって引き起こされるのでしょうか?
D Reed1, C Reed, G Stemmermann
1Honolulu Heart Program, HI 96817.
Circulation
|January 1, 1992
まとめ
高血圧,コレステロール,喫煙などの動脈硬化のリスク要因は,ほとんどの動脈動脈瘤と関連しています. この20年間の研究は,動脈硬化が動脈瘤発達の重要な要因であることを示唆しています.
科学分野:
- 心血管医学 心血管医学
- エピデミオロジー エピデミオロジー
- 病理学 パトロジー
背景:
- 大動脈動脈瘤の発達における動脈硬化症の議論の多い役割を調査した.
- ハワイの日本系男性8000人を超える20年間の追跡データを活用した.
研究 の 目的:
- 動脈硬化リスク要因と大動脈動脈瘤および解剖の発生率との関係を調べる.
- 動脈硬化症が大動脈動脈瘤の因果的な経路において必要な構成要素であるかどうかを判断する.
主な方法:
- 臨床的インシデントイベント (大動脈動脈瘤および解剖) と解剖データの分析.
- 大動脈動脈硬化と動脈瘤の基礎リスク要因を特定しました.
- 大動脈動脈瘤に対するリスク因子の比較と大動脈解剖の比較.
主要な成果:
- 174件の臨床イベントの中で,151件の大動脈動脈瘤と23件の大動脈解剖を特定しました.
- 大動脈動脈瘤 (高血圧,高コレステロール,喫煙) のベースラインリスク要因は,大動脈動脈硬化症のリスクを反映した.
- これらのリスク要因は,解剖した男性における大動脈動脈瘤とも関連していました.
- 大動脈解剖は,年齢特有の発生率を示し,先天的な感受性および他の原因要因を示唆し,主に高血圧によって予測されています.
結論:
- 動脈硬化のリスク要因は,このコホートにおける大動脈動脈瘤の大部分の発生に必要である可能性が高い.
- 動脈硬化自体は,ほとんどの大動脈動脈瘤の因果的な経路における重要な要素であるようです.
- この発見は,動脈硬化症をターゲットにすることで,大動脈動脈瘤の予防に意味を持つ.
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