運動している犬の缺血性心筋の冠動脈血管拡張剤の準備量
D D Laxson1, X Z Dai, D C Homans
1Department of Medicine, University of Minnesota, Minneapolis 55455.
Circulation
|January 1, 1992
まとめ
冠動脈血管拡張剤の準備は,運動中に缺血性心筋に持続する. これは,残ったマイクロ血管トーンが冠動脈狭窄症からの低血流に影響することを示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- 心筋動脈性缺血の研究について
- 冠動脈循環研究 冠動脈循環研究
背景:
- 以前の研究では,冠動脈血管拡張剤の準備がhypoperfused myocardiumで持続することが示唆されています.
- この研究は,冠動脈狭窄による急性運動誘発性心筋動脈不全の残留冠動脈血管運動トーンを調査しています.
研究 の 目的:
- 運動中の急性心筋不全症の冠動脈血管拡張器の残留トンの存在と範囲を決定する.
- アデノシンが心筋動脈の血流と機能に与える影響を評価する.
主な方法:
- 流れを制限する冠動脈狭窄症のトレッドミルの運動中に機器付きの犬で行われた研究.
- 冠動脈内アデノシン注入前およびその間,放射性マイクロ球を用いて測定された心筋血流量.
- 冠動脈の輸血圧は,アデノシンの効果を隔離するために一貫して維持されます.
主要な成果:
- 冠動脈狭窄による運動は,非血動性前部地域と比較して,不血性後部地域における血流を著しく減少させた.
- 冠内アデノシンは,缺血領域における心筋血流を有意に増加させ,継続的な血管拡張剤の準備を示唆した.
- アデノシン投与により,不血症領域における心筋断片の縮小は,輸血圧が変化しないにもかかわらず,改善した.
結論:
- アデノシン反応性冠動脈血管拡張剤の準備は,運動誘発性心筋梗塞症の間に存在します.
- 残留のマイクロ血管静脈圧縮器のトーンが,冠動脈狭窄によって引き起こされる心筋縮の重症に寄与する可能性があります.
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