ハイパートロフィック心筋病変症における突然心臓死
1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. 20892.
Circulation
|January 1, 1992
まとめ
ハイパートロフィック心筋症 (HCM) の突然死は,若い個人に影響し,しばしば低労力の活動中に起こります. アリズム障害や家族歴などの危険因子を特定することは,予防に不可欠です.
科学分野:
- 心臓病学 心臓病学
- 遺伝学 遺伝学とは
- 心臓発作による突然死.
背景:
- 急性死は,自然史の高圧性心筋病変 (HCM) の重要な側面です.
- 原因を理解し,リスクの高い患者を特定することは,激しい研究分野です.
- HCMに関連した突然死は,毎年患者の2〜3%で発生し,主に高齢の子供や若年成人で発生します.
研究 の 目的:
- ハイパートロフィック心筋症候群における突然死の原因と原因を調べる.
- リスクの高い患者の見込みの特定について議論する.
- HCMと突然死に関する進化する概念と知識を探求する.
主な方法:
- ハイパートロフィック心筋病症における突然死に関する既存の文献のレビュー.
- 患者の人口統計,臨床表現,診断試験の結果を含む,特定されたリスク要因の分析.
- 感染した個体における電気生理学的および血液動力学的発見の検討.
主要な成果:
- HCMにおける突然死は,典型的には,左心房壁が厚くなり,通常は最低限の身体活動中に,症状のない若い個人に影響を及ぼします.
- 少数の死亡は,激しい運動中に,またはその後に起こります.
- 特定された危険因子には,非持続的心室性低心率,突然死症の家族歴,昏睡などがあります.
結論:
- 電気生理学的研究は,高リスクの患者において,鼻腔またはヒス・パーキンジェ伝導疾患および誘導性不律を明らかにする.
- 誘導性心房不律症は,以前の昏睡または心停止と相関しています.
- 突然死の原因となる可能性のあるメカニズムには,不律性,伝導性疾患,流出管阻害,心筋不全症などがあります.
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