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Updated: Jul 17, 2026

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
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RNAポリメラーゼIIの転写によるCPD損傷認識

Florian Brueckner1, Ulrich Hennecke, Thomas Carell

  • 1Munich Center for Integrated Protein Science CiPS, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

Science (New York, N.Y.)
|February 10, 2007
PubMed
まとめ

細胞は,転写結合修復 (TCR) 中のRNAポリメラーゼII (Pol II) を阻害し,DNA損傷の反対側にある尿素を誤って組み込みます. この停滞はDNA修復に不可欠であり,損傷が除去されるまでポリメラーゼの進行を防止します.

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