葉酸欠乏症と子宮頸椎不形成症
C E Butterworth1, K D Hatch, M Macaluso
1Department of Nutrition Sciences, School of Medicine, University of Alabama, Birmingham 35294-3360.
JAMA
|February 1, 1992
まとめ
栄養不足,特に赤血球葉酸の低レベルは,特にヒトパピローマウイルス (HPV) 感染症と併用すると,若い女性の子宮頸椎不形成症のリスクを大幅に増加させます.
科学分野:
- 婦人科 婦人科について
- 栄養科学とは,栄養科学である.
- 腫瘍学 腫瘍学
背景:
- 子宮頸部不形成症は,若い女性に影響を与えるがん前疾患です.
- 栄養状態を含むリスク要因を理解することは,予防に不可欠です.
研究 の 目的:
- 栄養不足と,若い女性における子宮頸椎不形成症の発生率との関連を調査する.
- 特定の栄養素のレベルが,子宮頸椎不形成症を発症するリスクに影響するかどうかを判断する.
主な方法:
- 家族計画診療所とコルポスコピーの紹介からスクリーニングされた726人の女性を対象としたケース・コントロール研究.
- ロジスティック回帰モデルは,血液サンプルから12の栄養指標を含む,子宮頸部不形成症とさまざまな要因との関連を評価するために使用されました.
- ヒューマン・パピローマウイルス (HPV) 感染と栄養分レベルを分析した.
主要な成果:
- 子宮頸部不形成症と性パートナー数,均等性,経口避妊薬の使用,HPV-16感染との間に有意な関連性が見つかりました.
- 血の栄養分レベルは,一般的にリスクとの関連性を示さなかった.
- 低赤血球葉酸レベル (<660 nmol/L) は,HPV-16感染と有意に相互作用し,HPV-16の調整された確率比を5.1に増加させました.
結論:
- 低赤血球葉酸のレベルは,子宮頸椎不発症のリスクを高めます.
- 葉酸欠乏症は,特に,子宮頸部不形成症の発達におけるHPV-16感染の効果を高めます.
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