エストロゲンの標的部位は,雛の胚の脳にある

M C Martinez-Vargas, D B Gibson, M Sar

Science (New York, N.Y.)

|December 26, 1975

まとめ

チキン胚の脳内のエストロゲン標的細胞は,10日目までに,特に下垂体で現れる. これらの細胞は,行動やホルモン分泌に関連する脳の機能の発達に不可欠です.

科学分野:

神経内分泌学の神経内分泌学
発達神経科学とは
ステロイドホルモンの作用ステロイドホルモンの作用

背景:

エストロゲンは,脳の発達と機能において重要な役割を果たします.
エストロゲン標的細胞のタイミングと位置を理解することは,その組織的効果を理解するための鍵です.

研究の目的:

エストロゲン標的細胞の存在と位置を,鶏の胚の発達中の脳で特定する.
エストロゲンに敏感な神経領域の発達タイムラインを調査する.

主な方法:

[3H]エストラディオルを様々な発達段階のチキの胚に投与する.
ホルモンの吸収を視覚化し,標的細胞を特定するために脳組織のautoradiographic分析.

主要な成果:

エストロゲン標的細胞は,胚の10日目までにメディアル・プレオプティックとベントラル・ヒポタラミック領域で検出されました.
後の胚発達の過程で,テレンセファリック領域に追加の標的細胞が現れた.

結論:

中間視前頭部と内側下頭部には,鶏の胚の初期のエストロゲン標的細胞が含まれています.
これらのホルモンを集約する細胞は,性ステロイドが脳の発達に及ぼす影響の解剖学的基礎を形成し,性行為,攻撃性,およびゴナドトロピンの分泌に影響を与えます.

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