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p53-MDM2複合体における結合誘発折りたたみ

Hai-Feng Chen1, Ray Luo

  • 1Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.

Journal of the American Chemical Society
|February 17, 2007
PubMed
まとめ

p53-MDM2の相互作用はMDM2を安定させ,結合と折り畳みは機能に不可欠である. 分子ダイナミクスシミュレーションは,結合されたMDM2と結合されていないMDM2の異なる展開経路を明らかにし,構造的安定性の違いを強調しています.

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