システミック・ルプス・エリテマトーソス症です
David P D'Cruz1, Munther A Khamashta, Graham R V Hughes
1Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK. david.d'cruz@kcl.ac.uk
Lancet (London, England)
|February 20, 2007
まとめ
システミック・ルプス・エリテマトーサス (SLE) は,主に女性に影響を与える複雑な自己免疫疾患です. 最近の進歩は,疫学,遺伝学,臓器特異的症状,および生物学的薬剤のような新しい治療法をカバーしています.
科学分野:
- 病理学・リウマトロジー・免疫学
- 自己免疫疾患 自己免疫疾患
- 結合組織疾患 結合組織疾患
背景:
- システミック・ルプス・エリテマトーサス (SLE) は慢性的な自己免疫結合組織疾患である.
- それは主に女性に影響し,民族ごとに違いがあります.
- 診断は,臨床表現と自己抗体の検出に依存しています.
研究 の 目的:
- SLEにおける最近の進歩をレビューする.
- 疫学,遺伝学,および臨床的症状を含む主要な分野をカバーする.
- 新興の治療戦略について議論する.
主な方法:
- 文献レビューと現在の研究の合成.
- SLEの疫学,遺伝学,臨床的側面に焦点を当てます.
- 新しい治療方法の評価.
主要な成果:
- SLEは,心血管,腎臓 (ルプス腎炎),中枢神経系 (CNS) を含む複数の器官系に影響を与えます.
- アンチフォスフォリピド症候群は,重大な併発症である.
- 病気の活動評価と妊娠に関連する問題は,管理の重要な側面です.
結論:
- SLEの疫学と遺伝学の包括的な理解は進化しています.
- 心血管リスク,腎炎,中枢神経系疾患の理解における進歩は極めて重要です.
- 生物学的薬剤とミコフェノラートモフェチルを含む新しい治療法は,SLE管理のための新しい治療方法を提供します.
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