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関連する概念動画

Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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関連する実験動画

Updated: May 11, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

哺乳類のエピジェノーム

Bradley E Bernstein1, Alexander Meissner, Eric S Lander

  • 1Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA. bbernstein@partners.org

Cell
|February 27, 2007
PubMed
まとめ

エピゲノムは,DNAとヒストンタンパク質の遺伝的変化を含み,ゲノム機能を調節します. その複雑な組成を理解することは,多様な生物学的文脈における遺伝子発現を解読する上で極めて重要です.

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • エピジェネティクス エピジェネティクス

背景:

  • DNAとヒストンタンパク質の化学的改変により,クロマチンの構造とゲノム機能を制御する規制ネットワークが形成されます.
  • エピゲノムは,遺伝学,細胞系統,環境の影響を受け,ゲノム全体の遺伝的変化を表しています.
  • ヒト後ゲノムシーケンシングの研究は,発達,組織,疾患における遺伝子発現における表遺伝的変化を理解することに重点を置いています.

研究 の 目的:

  • エピゲノム研究における現在の研究努力をレビューする.
  • 大規模な研究,新興技術,エピゲノム研究における課題を強調する.
  • エピジェネティック改変とゲノム機能におけるその役割に関する包括的な見解を提供すること.

主な方法:

  • 現在の文献のレビューと大規模なエピゲノム研究.
  • エピゲノム分析のための新興技術に重点を置く.
  • エピゲノム組成に影響を与える要因の分析.

主要な成果:

  • エピゲノムは,遺伝情報の解釈に不可欠な規則のダイナミックな層です.
  • 大規模な研究は,エピゲノム変異の包括的な理解のために不可欠です.

さらに関連する動画

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
07:50

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

Published on: August 29, 2018

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

関連する実験動画

Last Updated: May 11, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
07:50

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

Published on: August 29, 2018

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

  • 技術の進歩により,表遺伝子をマッピングし,分析する能力が向上しています.

    • 結論:

    • エピゲノムに関する包括的な理解は,生物学的および医学的な研究を前進させるために不可欠です.
    • 将来の研究は,大規模なデータと新しいテクノロジーの統合に焦点を当てるべきです.
    • エピゲノム研究の課題に取り組むことは,健康と病気に関する新しい洞察を開くでしょう.