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Updated: Jul 16, 2026

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
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Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

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活性X染色体上の遺伝子体特異的メチル化

Asaf Hellman1, Andrew Chess

  • 1Center for Human Genetic Research and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA. hellman@chgr.mgh.harvard.edu

Science (New York, N.Y.)
|February 27, 2007
PubMed
まとめ

活性X染色体 (Xa) は,不活性X染色体 (Xi) よりも,遺伝子体内のDNAメチル化が有意に多く示される. この微分メチル化パターンは,遺伝子発現の可能性に影響を与える二重プログラムを示唆する.

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Epigenetic Regulation01:46

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Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

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