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Updated: Jul 16, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
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Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

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溶液,固体状態,およびHsp90結合部位におけるリガンド構成の関係:ゲルダナミシンとラジチコル

Pahk Thepchatri1, Tomasso Eliseo, Daniel O Cicero

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.

Journal of the American Chemical Society
|February 28, 2007
PubMed
まとめ

溶液中の分子柔軟性が薬剤結合にどのように影響するかを理解することは極めて重要です. この研究は,溶液構成が熱ショックタンパク質90 (Hsp90) 阻害剤の薬物結合姿勢を正確に予測することを示しています.

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